Relaxin gene delivery modulates macrophages to resolve cancer fibrosis and synergizes with immune checkpoint blockade therapy

Cancer fibrosis serves as a major therapeutic barrier in desmoplastic tumors. Relaxin (RLN; a systemic hormone) is efficacious to decrease fibrosis, but the in vivo mechanism of action is not clear. Considering the localization of relaxin family peptide receptor type 1 (RXFP1), the receptor for RLN,...

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Detalles Bibliográficos
Autores principales: Zhou, Xuefei, Liu, Yun, Hu, Mengying, Wang, Menglin, Liu, Xiangrui, Huang, Leaf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7888957/
https://www.ncbi.nlm.nih.gov/pubmed/33597232
http://dx.doi.org/10.1126/sciadv.abb6596

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7888957/
https://www.ncbi.nlm.nih.gov/pubmed/33597232
http://dx.doi.org/10.1126/sciadv.abb6596

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