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Relaxin gene delivery modulates macrophages to resolve cancer fibrosis and synergizes with immune checkpoint blockade therapy

Cancer fibrosis serves as a major therapeutic barrier in desmoplastic tumors. Relaxin (RLN; a systemic hormone) is efficacious to decrease fibrosis, but the in vivo mechanism of action is not clear. Considering the localization of relaxin family peptide receptor type 1 (RXFP1), the receptor for RLN,...

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Detalles Bibliográficos
Autores principales:	Zhou, Xuefei, Liu, Yun, Hu, Mengying, Wang, Menglin, Liu, Xiangrui, Huang, Leaf
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2021
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7888957/ https://www.ncbi.nlm.nih.gov/pubmed/33597232 http://dx.doi.org/10.1126/sciadv.abb6596

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