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Activin A backs-up TGF-ß to promote regulatory T cells
The mechanisms accountable for the infiltration of regulatory T cells into an irradiated tumor remain elusive. In our recent study, we demonstrate that activin A promotes regulatory T cells in tumors, and impairs anti-tumor immune responses induced by radiotherapy and TGF-β blockade. Dual blockade o...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7889161/ https://www.ncbi.nlm.nih.gov/pubmed/33628624 http://dx.doi.org/10.1080/2162402X.2021.1883288 |
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author | De Martino, Mara Daviaud, Camille Vanpouille-Box, Claire |
author_facet | De Martino, Mara Daviaud, Camille Vanpouille-Box, Claire |
author_sort | De Martino, Mara |
collection | PubMed |
description | The mechanisms accountable for the infiltration of regulatory T cells into an irradiated tumor remain elusive. In our recent study, we demonstrate that activin A promotes regulatory T cells in tumors, and impairs anti-tumor immune responses induced by radiotherapy and TGF-β blockade. Dual blockade of activin A and TGF-β may be necessary to reduce regulatory T cells mediated immunosuppression driven by radiation therapy. |
format | Online Article Text |
id | pubmed-7889161 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-78891612021-02-23 Activin A backs-up TGF-ß to promote regulatory T cells De Martino, Mara Daviaud, Camille Vanpouille-Box, Claire Oncoimmunology Author’s View The mechanisms accountable for the infiltration of regulatory T cells into an irradiated tumor remain elusive. In our recent study, we demonstrate that activin A promotes regulatory T cells in tumors, and impairs anti-tumor immune responses induced by radiotherapy and TGF-β blockade. Dual blockade of activin A and TGF-β may be necessary to reduce regulatory T cells mediated immunosuppression driven by radiation therapy. Taylor & Francis 2021-02-11 /pmc/articles/PMC7889161/ /pubmed/33628624 http://dx.doi.org/10.1080/2162402X.2021.1883288 Text en © 2021 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Author’s View De Martino, Mara Daviaud, Camille Vanpouille-Box, Claire Activin A backs-up TGF-ß to promote regulatory T cells |
title | Activin A backs-up TGF-ß to promote regulatory T cells |
title_full | Activin A backs-up TGF-ß to promote regulatory T cells |
title_fullStr | Activin A backs-up TGF-ß to promote regulatory T cells |
title_full_unstemmed | Activin A backs-up TGF-ß to promote regulatory T cells |
title_short | Activin A backs-up TGF-ß to promote regulatory T cells |
title_sort | activin a backs-up tgf-ß to promote regulatory t cells |
topic | Author’s View |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7889161/ https://www.ncbi.nlm.nih.gov/pubmed/33628624 http://dx.doi.org/10.1080/2162402X.2021.1883288 |
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