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Activin A backs-up TGF-ß to promote regulatory T cells

The mechanisms accountable for the infiltration of regulatory T cells into an irradiated tumor remain elusive. In our recent study, we demonstrate that activin A promotes regulatory T cells in tumors, and impairs anti-tumor immune responses induced by radiotherapy and TGF-β blockade. Dual blockade o...

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Detalles Bibliográficos
Autores principales: De Martino, Mara, Daviaud, Camille, Vanpouille-Box, Claire
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7889161/
https://www.ncbi.nlm.nih.gov/pubmed/33628624
http://dx.doi.org/10.1080/2162402X.2021.1883288
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author De Martino, Mara
Daviaud, Camille
Vanpouille-Box, Claire
author_facet De Martino, Mara
Daviaud, Camille
Vanpouille-Box, Claire
author_sort De Martino, Mara
collection PubMed
description The mechanisms accountable for the infiltration of regulatory T cells into an irradiated tumor remain elusive. In our recent study, we demonstrate that activin A promotes regulatory T cells in tumors, and impairs anti-tumor immune responses induced by radiotherapy and TGF-β blockade. Dual blockade of activin A and TGF-β may be necessary to reduce regulatory T cells mediated immunosuppression driven by radiation therapy.
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spelling pubmed-78891612021-02-23 Activin A backs-up TGF-ß to promote regulatory T cells De Martino, Mara Daviaud, Camille Vanpouille-Box, Claire Oncoimmunology Author’s View The mechanisms accountable for the infiltration of regulatory T cells into an irradiated tumor remain elusive. In our recent study, we demonstrate that activin A promotes regulatory T cells in tumors, and impairs anti-tumor immune responses induced by radiotherapy and TGF-β blockade. Dual blockade of activin A and TGF-β may be necessary to reduce regulatory T cells mediated immunosuppression driven by radiation therapy. Taylor & Francis 2021-02-11 /pmc/articles/PMC7889161/ /pubmed/33628624 http://dx.doi.org/10.1080/2162402X.2021.1883288 Text en © 2021 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Author’s View
De Martino, Mara
Daviaud, Camille
Vanpouille-Box, Claire
Activin A backs-up TGF-ß to promote regulatory T cells
title Activin A backs-up TGF-ß to promote regulatory T cells
title_full Activin A backs-up TGF-ß to promote regulatory T cells
title_fullStr Activin A backs-up TGF-ß to promote regulatory T cells
title_full_unstemmed Activin A backs-up TGF-ß to promote regulatory T cells
title_short Activin A backs-up TGF-ß to promote regulatory T cells
title_sort activin a backs-up tgf-ß to promote regulatory t cells
topic Author’s View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7889161/
https://www.ncbi.nlm.nih.gov/pubmed/33628624
http://dx.doi.org/10.1080/2162402X.2021.1883288
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