Combining random mutagenesis, structure-guided design and next-generation sequencing to mitigate polyreactivity of an anti-IL-21R antibody

Despite substantial technological advances in antibody library and display platform development, the number of approved biotherapeutics from displayed libraries remains limited. In vivo, 20–50% of peripheral B cells undergo a process of receptor editing, which modifies the variable and junctional re...

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Detalles Bibliográficos
Autores principales: Campbell, Sharon M., DeBartolo, Joseph, Apgar, James R., Mosyak, Lydia, McManus, Virginie, Beyer, Sonia, Bennett, Eric M., Lambert, Matthew, Cunningham, Orla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7889167/
https://www.ncbi.nlm.nih.gov/pubmed/33557673
http://dx.doi.org/10.1080/19420862.2021.1883239

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7889167/
https://www.ncbi.nlm.nih.gov/pubmed/33557673
http://dx.doi.org/10.1080/19420862.2021.1883239

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