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Combining random mutagenesis, structure-guided design and next-generation sequencing to mitigate polyreactivity of an anti-IL-21R antibody

Despite substantial technological advances in antibody library and display platform development, the number of approved biotherapeutics from displayed libraries remains limited. In vivo, 20–50% of peripheral B cells undergo a process of receptor editing, which modifies the variable and junctional re...

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Detalles Bibliográficos
Autores principales:	Campbell, Sharon M., DeBartolo, Joseph, Apgar, James R., Mosyak, Lydia, McManus, Virginie, Beyer, Sonia, Bennett, Eric M., Lambert, Matthew, Cunningham, Orla
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2021
Materias:	Reports
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7889167/ https://www.ncbi.nlm.nih.gov/pubmed/33557673 http://dx.doi.org/10.1080/19420862.2021.1883239

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