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Discovery of new quinolines as potent colchicine binding site inhibitors: design, synthesis, docking studies, and anti-proliferative evaluation

Discovering of new anticancer agents with potential activity against tubulin polymerisation is still a promising approach. Colchicine binding site inhibitors are the most relevant anti-tubulin polymerisation agents. Thus, new quinoline derivatives have been designed and synthesised to possess the sa...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Hagras, Mohamed, El Deeb, Moshira A., Elzahabi, Heba S. A., Elkaeed, Eslam B., Mehany, Ahmed B. M., Eissa, Ibrahim H.
Format: Online Artikel Text
Sprache:English
Veröffentlicht: Taylor & Francis 2021
Schlagworte:
Online Zugang:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7889231/
https://www.ncbi.nlm.nih.gov/pubmed/33588683
http://dx.doi.org/10.1080/14756366.2021.1883598