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Accelerated sonothrombolysis with Definity in a xenographic porcine cerebral thromboembolism model
Adjuvant ultrasound at 2 MHz with or without an ultrasound contrast agent improves the rate of thrombus resolution by recombinant tissue plasminogen activator (rt-PA) in laboratory and clinical studies. A sub-megahertz approach can further expand this therapy to a subset of patients with an insuffic...
Autores principales: | Kleven, Robert T., Karani, Kunal B., Hilvert, Nicole, Ford, Samantha M., Mercado-Shekhar, Karla P., Racadio, John M., Rao, Marepalli B., Abruzzo, Todd A., Holland, Christy K. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7889614/ https://www.ncbi.nlm.nih.gov/pubmed/33597659 http://dx.doi.org/10.1038/s41598-021-83442-3 |
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