Molecular basis of nucleosomal H3K36 methylation by NSD methyltransferases

The NSD family histone methyltransferases, including NSD1, NSD2 and NSD3, play crucial roles in chromatin regulation and are implicated in oncogenesis(1,2). NSD enzymes exhibit an auto-inhibitory state that is relieved by nucleosome engagement, allowing for H3K36 di-methylation catalysis(3–7). Howev...

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Detalles Bibliográficos
Autores principales: Li, Wanqiu, Tian, Wei, Yuan, Gang, Deng, Pujuan, Sengupta, Deepanwita, Cheng, Zhongjun, Cao, Yinghua, Ren, Jiahao, Qin, Yan, Zhou, Yuqiao, Jia, Yulin, Gozani, Or, Patel, Dinshaw J., Wang, Zhanxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7889650/
https://www.ncbi.nlm.nih.gov/pubmed/33361816
http://dx.doi.org/10.1038/s41586-020-03069-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7889650/
https://www.ncbi.nlm.nih.gov/pubmed/33361816
http://dx.doi.org/10.1038/s41586-020-03069-8

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