Whole genome doubling confers unique genetic vulnerabilities on tumor cells

Whole genome doubling (WGD) occurs early in tumorigenesis and generates genetically unstable tetraploid cells that fuel tumor development(1,2). Cells that undergo WGD (WGD(+)) must adapt to accommodate their abnormal tetraploid state; however, the nature of these adaptations, and whether they confer...

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Detalles Bibliográficos
Autores principales: Quinton, Ryan J., DiDomizio, Amanda, Vittoria, Marc A., Kotýnková, Kristýna, Ticas, Carlos J., Patel, Sheena, Koga, Yusuke, Vakhshoorzadeh, Jasmine, Hermance, Nicole, Kuroda, Taruho S., Parulekar, Neha, Taylor, Alison M., Manning, Amity L., Campbell, Joshua D., Ganem, Neil J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7889737/
https://www.ncbi.nlm.nih.gov/pubmed/33505027
http://dx.doi.org/10.1038/s41586-020-03133-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7889737/
https://www.ncbi.nlm.nih.gov/pubmed/33505027
http://dx.doi.org/10.1038/s41586-020-03133-3

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