Obeticholic acid ameliorates severity of Clostridioides difficile infection in high fat diet-induced obese mice

Severe Clostridiodes difficile infection (CDI) is life-threatening and responds poorly to treatment. Obesity is associated with development of severe CDI. Therefore, to define the mechanisms that exacerbate disease severity, we examined CDI pathogenesis in high-fat diet (HFD)-fed obese mice. Compare...

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Detalles Bibliográficos
Autores principales: Jose, Shinsmon, Mukherjee, Anindita, Horrigan, Olivia, Setchell, Kenneth D. R., Zhang, Wujuan, Moreno-Fernandez, Maria E., Andersen, Heidi, Sharma, Divya, Haslam, David B., Divanovic, Senad, Madan, Rajat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7889747/
https://www.ncbi.nlm.nih.gov/pubmed/32811993
http://dx.doi.org/10.1038/s41385-020-00338-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7889747/
https://www.ncbi.nlm.nih.gov/pubmed/32811993
http://dx.doi.org/10.1038/s41385-020-00338-7

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