Ex vivo modelling of PD-1/PD-L1 immune checkpoint blockade under acute, chronic, and exhaustion-like conditions of T-cell stimulation

Blockade of PD-1/PD-L1 interactions is proving an exciting, durable therapeutic modality in a range of cancers whereby T cells are released from checkpoint inhibition to revive their inherent anti-tumour activity. Here we have studied various ways to model ex vivo T cell function in order to compare...

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Detalles Bibliográficos
Autores principales: Roberts, Alexander, Bentley, Lindsay, Tang, Tina, Stewart, Fay, Pallini, Chiara, Juvvanapudi, Joel, Wallace, Graham R., Cooper, Alison J., Scott, Aaron, Thickett, David, Lugg, Sebastian T., Bancroft, Hollie, Hemming, Bridget, Ferris, Charlotte, Langman, Gerald, Robinson, Andrew, Chapman, Joanne, Naidu, Babu, Pinkney, Thomas, Taylor, Graham S., Brock, Kristian, Stamataki, Zania, Brady, Catherine A., Curnow, S. John, Gordon, John, Qureshi, Omar, Barnes, Nicholas M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7889918/
https://www.ncbi.nlm.nih.gov/pubmed/33597595
http://dx.doi.org/10.1038/s41598-021-83612-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7889918/
https://www.ncbi.nlm.nih.gov/pubmed/33597595
http://dx.doi.org/10.1038/s41598-021-83612-3

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