Cargando…

Ex vivo modelling of PD-1/PD-L1 immune checkpoint blockade under acute, chronic, and exhaustion-like conditions of T-cell stimulation

Blockade of PD-1/PD-L1 interactions is proving an exciting, durable therapeutic modality in a range of cancers whereby T cells are released from checkpoint inhibition to revive their inherent anti-tumour activity. Here we have studied various ways to model ex vivo T cell function in order to compare...

Descripción completa

Detalles Bibliográficos
Autores principales:	Roberts, Alexander, Bentley, Lindsay, Tang, Tina, Stewart, Fay, Pallini, Chiara, Juvvanapudi, Joel, Wallace, Graham R., Cooper, Alison J., Scott, Aaron, Thickett, David, Lugg, Sebastian T., Bancroft, Hollie, Hemming, Bridget, Ferris, Charlotte, Langman, Gerald, Robinson, Andrew, Chapman, Joanne, Naidu, Babu, Pinkney, Thomas, Taylor, Graham S., Brock, Kristian, Stamataki, Zania, Brady, Catherine A., Curnow, S. John, Gordon, John, Qureshi, Omar, Barnes, Nicholas M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7889918/ https://www.ncbi.nlm.nih.gov/pubmed/33597595 http://dx.doi.org/10.1038/s41598-021-83612-3

Ejemplares similares

Reinvigorating exhausted HIV-specific T cells via PD-1–PD-1 ligand blockade
por: Freeman, Gordon J., et al.
Publicado: (2006)

Differential expression of PD-1 and Tim-3 marks activation versus exhaustion status of T cells in the tumor microenvironment
por: Li, Jing, et al.
Publicado: (2014)

Fully automated real-time PCR for EGFR testing in non-small cell lung carcinoma
por: Colling, Richard, et al.
Publicado: (2018)

Small-molecule inhibitors of PD-1/PD-L1 immune checkpoint alleviate the PD-L1-induced exhaustion of T-cells
por: Skalniak, Lukasz, et al.
Publicado: (2017)

Indirect Impact of PD-1/PD-L1 Blockade on a Murine Model of NK Cell Exhaustion
por: Alvarez, Maite, et al.
Publicado: (2020)

Cigarette smoke exposure and alveolar macrophages: mechanisms for lung disease
por: Lugg, Sebastian T, et al.
Publicado: (2022)

The liver as an immunological barrier redefined by single‐cell analysis
por: Stamataki, Zania, et al.
Publicado: (2020)

In Vitro Systems for the Study of Hepatitis C Virus Infection
por: Wilson, Garrick K., et al.
Publicado: (2012)

Sudden onset hepatitis in children
por: Kelly, Deirdre A., et al.
Publicado: (2022)

Genetic absence of PD-1 promotes accumulation of terminally differentiated exhausted CD8(+) T cells
por: Odorizzi, Pamela M., et al.
Publicado: (2015)

The PD-1/PD-L1 (B7-H1) Pathway in Chronic Infection-Induced Cytotoxic T Lymphocyte Exhaustion
por: Hofmeyer, Kimberly A., et al.
Publicado: (2011)

Circulating Exhausted PD-1(+)CD39(+) Helper CD4 T Cells Are Tumor-Antigen-Specific and Predict Response to PD-1/PD-L1 Axis Blockade
por: Martinez-Gomez, Carlos, et al.
Publicado: (2022)

PD-1 promotes immune exhaustion by inducing antiviral T cell motility paralysis
por: Zinselmeyer, Bernd H., et al.
Publicado: (2013)

T cell subtype profiling measures exhaustion and predicts anti-PD-1 response
por: Schillebeeckx, Ian, et al.
Publicado: (2022)

PD-1 blockade restores helper activity of tumor-infiltrating, exhausted PD-1(hi)CD39(+) CD4 T cells
por: Balança, Camille-Charlotte, et al.
Publicado: (2021)

Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8(+) T cell exhaustion
por: Peng, David H., et al.
Publicado: (2020)

The identification of TCF1(+) progenitor exhausted T cells in THRLBCL may predict a better response to PD-1/PD-L1 blockade
por: Tabanelli, Valentina, et al.
Publicado: (2022)

PD-1 and BTLA and CD8(+) T-cell “exhaustion” in cancer: “Exercising” an alternative viewpoint
por: Haymaker, Cara, et al.
Publicado: (2012)

PD-1 mediates functional exhaustion of activated NK cells in patients with Kaposi sarcoma
por: Beldi-Ferchiou, Asma, et al.
Publicado: (2016)

PD‐1‐induced T cell exhaustion is controlled by a Drp1‐dependent mechanism
por: Simula, Luca, et al.
Publicado: (2021)

Abbreviated MDS-UPDRS for Remote Monitoring in PD Identified Using Exhaustive Computational Search
por: Morinan, Gareth, et al.
Publicado: (2022)

A CD64/FcγRI-mediated mechanism hijacks PD-1 from PD-L1/2 interaction and enhances anti-PD-1 functional recovery of exhausted T cells
por: Joo, Victor, et al.
Publicado: (2023)

Clearance of Apoptotic Cells by Tissue Epithelia: A Putative Role for Hepatocytes in Liver Efferocytosis
por: Davies, Scott P., et al.
Publicado: (2018)

Understanding COVID-19: are children the key?
por: Warner, Suz, et al.
Publicado: (2021)

PD-1 Blockade Modulates Functional Activities of Exhausted-Like T Cell in Patients With Cutaneous Leishmaniasis
por: Garcia de Moura, Renan, et al.
Publicado: (2021)

BET bromodomain inhibition rescues PD-1-mediated T-cell exhaustion in acute myeloid leukemia
por: Zhong, Mengjun, et al.
Publicado: (2022)

PD-1 Immune Checkpoint Blockade and PSGL-1 Inhibition Synergize to Reinvigorate Exhausted T Cells
por: Viramontes, Karla M., et al.
Publicado: (2022)

Synergistic Reversal of Intrahepatic HCV-Specific CD8 T Cell Exhaustion by Combined PD-1/CTLA-4 Blockade
por: Nakamoto, Nobuhiro, et al.
Publicado: (2009)

Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity
por: Sakuishi, Kaori, et al.
Publicado: (2011)

Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity
por: Sakuishi, Kaori, et al.
Publicado: (2010)

Re-Evaluation of PD-1 Expression by T Cells as a Marker for Immune Exhaustion during SIV Infection
por: Hong, Jung Joo, et al.
Publicado: (2013)

CD40 Activation Rescues Antiviral CD8(+) T Cells from PD-1-Mediated Exhaustion
por: Isogawa, Masanori, et al.
Publicado: (2013)

Correction to: BET bromodomain inhibition rescues PD-1-mediated T-cell exhaustion in acute myeloid leukemia
por: Zhong, Mengjun, et al.
Publicado: (2022)

The increasing need for biomarkers in intensive care unit-acquired weakness - are microRNAs the solution?
por: Lugg, Sebastian T, et al.
Publicado: (2015)

Optimal Vitamin D Supplementation Levels for Cardiovascular Disease Protection
por: Lugg, Sebastian T., et al.
Publicado: (2015)

Regulation of PD-1/PD-L1 pathway and resistance to PD-1/PD-L1 blockade
por: Bai, Jie, et al.
Publicado: (2017)

PD-1(+) CD8(+) T cells are exhausted in tumours and functional in draining lymph nodes of colorectal cancer patients
por: Wu, X, et al.
Publicado: (2014)

Characterization of age‐associated exhausted CD8(+) T cells defined by increased expression of Tim‐3 and PD‐1
por: Lee, Kyoo‐A, et al.
Publicado: (2016)

Correction: CD40 Activation Rescues Antiviral CD8(+) T Cells from PD-1-Mediated Exhaustion
por: Isogawa, Masanori, et al.
Publicado: (2016)

Expression of LAG-3 defines exhaustion of intratumoral PD-1(+) T cells and correlates with poor outcome in follicular lymphoma
por: Yang, Zhi-Zhang, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_o8dupfhgltuen3jsfcnii29agq