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In silico designing of putative peptides for targeting pathological protein Htt in Huntington's disease

Huntington's disease is a neurodegenerative disease caused by CAG repeat in the first exon of HTT (Huntingtin) gene, leading to abnormal form of Htt protein containing enlarged polyglutamine strands of variable length that stick together to form aggregates and is toxic to brain causing brain da...

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Detalles Bibliográficos
Autores principales: Kohli, Harleen, Kumar, Pravir, Ambasta, Rashmi K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7890153/
https://www.ncbi.nlm.nih.gov/pubmed/33659724
http://dx.doi.org/10.1016/j.heliyon.2021.e06088