Clinical Pharmacology of Clazosentan, a Selective Endothelin A Receptor Antagonist for the Prevention and Treatment of aSAH-Related Cerebral Vasospasm

Aneurysmal subarachnoid hemorrhage (aSAH) may lead to cerebral vasospasm and is associated with significant morbidity and mortality. It represents a major unmet medical need due to few treatment options with limited efficacy. The role of endothelin-1 (ET-1) and its receptor ET(A) in the pathogenesis...

Descripción completa

Detalles Bibliográficos
Autores principales: Juif, Pierre-Eric, Dingemanse, Jasper, Ufer, Mike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7890197/
https://www.ncbi.nlm.nih.gov/pubmed/33613288
http://dx.doi.org/10.3389/fphar.2020.628956

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7890197/
https://www.ncbi.nlm.nih.gov/pubmed/33613288
http://dx.doi.org/10.3389/fphar.2020.628956

Ejemplares similares