Deciphering the Mechanism of Inhibition of SERCA1a by Sarcolipin Using Molecular Simulations

SERCA1a is an ATPase calcium pump that transports Ca(2+) from the cytoplasm to the sarco/endoplasmic reticulum lumen. Sarcolipin (SLN), a transmembrane peptide, regulates the activity of SERCA1a by decreasing its Ca(2+) transport rate, but its mechanism of action is still not well-understood. To dec...

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Detalles Bibliográficos
Autores principales: Barbot, Thomas, Beswick, Veronica, Montigny, Cédric, Quiniou, Éric, Jamin, Nadège, Mouawad, Liliane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7890198/
https://www.ncbi.nlm.nih.gov/pubmed/33614704
http://dx.doi.org/10.3389/fmolb.2020.606254

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7890198/
https://www.ncbi.nlm.nih.gov/pubmed/33614704
http://dx.doi.org/10.3389/fmolb.2020.606254

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