Structure dynamics of ApoA-I amyloidogenic variants in small HDL increase their ability to mediate cholesterol efflux

Apolipoprotein A-I (ApoA-I) of high density lipoproteins (HDLs) is essential for the transportation of cholesterol between peripheral tissues and the liver. However, specific mutations in ApoA-I of HDLs are responsible for a late-onset systemic amyloidosis, the pathological accumulation of protein f...

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Detalles Bibliográficos
Autores principales: Nilsson, Oktawia, Lindvall, Mikaela, Obici, Laura, Ekström, Simon, Lagerstedt, Jens O., Del Giudice, Rita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7890215/
https://www.ncbi.nlm.nih.gov/pubmed/33410751
http://dx.doi.org/10.1194/jlr.RA120000920

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7890215/
https://www.ncbi.nlm.nih.gov/pubmed/33410751
http://dx.doi.org/10.1194/jlr.RA120000920

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