Systematic improvements in lentiviral transduction of primary human natural killer cells undergoing ex vivo expansion

Transduction of primary human natural killer (NK) cells with lentiviral vectors has historically been challenging. We sought to evaluate multiple parameters to optimize lentiviral transduction of human peripheral blood NK cells being expanded to large numbers using a good manufacturing practice (GMP...

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Detalles Bibliográficos
Autores principales: Allan, David S.J., Chakraborty, Mala, Waller, Giacomo C., Hochman, Michael J., Poolcharoen, Akkapon, Reger, Robert N., Childs, Richard W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7890427/
https://www.ncbi.nlm.nih.gov/pubmed/33665226
http://dx.doi.org/10.1016/j.omtm.2021.01.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7890427/
https://www.ncbi.nlm.nih.gov/pubmed/33665226
http://dx.doi.org/10.1016/j.omtm.2021.01.008

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