Deficiency of Microglial Autophagy Increases the Density of Oligodendrocytes and Susceptibility to Severe Forms of Seizures

Excessive activation of mTOR in microglia impairs CNS homeostasis and causes severe epilepsy. Autophagy constitutes an important part of mTOR signaling. The contribution of microglial autophagy to CNS homeostasis and epilepsy remains to be determined. Here, we report that ATG7KO mice deficient for a...

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Detalles Bibliográficos
Autores principales: Alam, Mahabub Maraj, Zhao, Xiao-Feng, Liao, Yuan, Mathur, Ramkumar, McCallum, Sarah E., Mazurkiewicz, Joseph E., Adamo, Matthew A., Feustel, Paul, Belin, Sophie, Poitelon, Yannick, Zhu, Xinjun Cindy, Huang, Yunfei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2021
Materias:
Research Article: New Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7890520/
https://www.ncbi.nlm.nih.gov/pubmed/33472865
http://dx.doi.org/10.1523/ENEURO.0183-20.2021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7890520/
https://www.ncbi.nlm.nih.gov/pubmed/33472865
http://dx.doi.org/10.1523/ENEURO.0183-20.2021

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