Reprogramming of glutamine metabolism via glutamine synthetase silencing induces cisplatin resistance in A2780 ovarian cancer cells

BACKGROUND: Cisplatin (CDDP) significantly prolongs survival in various cancers, but many patients also develop resistance that results in treatment failure. Thus, this study aimed to elucidate the underlying mechanisms by which ovarian cancer cells acquire CDDP resistance. METHODS: We evaluated the...

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Detalles Bibliográficos
Autores principales: Guo, Jing, Satoh, Kiyotoshi, Tabata, Sho, Mori, Masaru, Tomita, Masaru, Soga, Tomoyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7891143/
https://www.ncbi.nlm.nih.gov/pubmed/33596851
http://dx.doi.org/10.1186/s12885-021-07879-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7891143/
https://www.ncbi.nlm.nih.gov/pubmed/33596851
http://dx.doi.org/10.1186/s12885-021-07879-5

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