N‐Heterocyclization in Gliotoxin Biosynthesis is Catalyzed by a Distinct Cytochrome P450 Monooxygenase

Gliotoxin and related epidithiodiketopiperazines (ETP) from diverse fungi feature highly functionalized hydroindole scaffolds with an array of medicinally and ecologically relevant activities. Mutation analysis, heterologous reconstitution, and biotransformation experiments revealed that a cytochrom...

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Detalles Bibliográficos
Autores principales: Scharf, Daniel H., Chankhamjon, Pranatchareeya, Scherlach, Kirstin, Dworschak, Jan, Heinekamp, Thorsten, Roth, Martin, Brakhage, Axel A., Hertweck, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7891397/
https://www.ncbi.nlm.nih.gov/pubmed/32835438
http://dx.doi.org/10.1002/cbic.202000550

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7891397/
https://www.ncbi.nlm.nih.gov/pubmed/32835438
http://dx.doi.org/10.1002/cbic.202000550

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