Efficient Chemical Protein Synthesis using Fmoc‐Masked N‐Terminal Cysteine in Peptide Thioester Segments

We report an operationally simple method to facilitate chemical protein synthesis by fully convergent and one‐pot native chemical ligations utilizing the fluorenylmethyloxycarbonyl (Fmoc) moiety as an N‐masking group of the N‐terminal cysteine of the middle peptide thioester segment(s). The Fmoc gro...

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Detalles Bibliográficos
Autores principales: Kar, Abhisek, Mannuthodikayil, Jamsad, Singh, Sameer, Biswas, Anamika, Dubey, Puneet, Das, Amit, Mandal, Kalyaneswar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7891605/
https://www.ncbi.nlm.nih.gov/pubmed/32333711
http://dx.doi.org/10.1002/anie.202000491

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7891605/
https://www.ncbi.nlm.nih.gov/pubmed/32333711
http://dx.doi.org/10.1002/anie.202000491

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