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Activation of the μ‐opioid receptor by alicyclic fentanyls: Changes from high potency full agonists to low potency partial agonists with increasing alicyclic substructure

Fentanyl analogs represent an important group of new psychoactive substances and knowing their efficacy and potency might assist in interpreting observed concentrations. The potency of fentanyl analogs can be estimated from in vitro studies and can be used to establish structure–activity relationshi...

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Detalles Bibliográficos
Autores principales: Åstrand, Anna, Vikingsson, Svante, Jakobsen, Ingrid, Björn, Niclas, Kronstrand, Robert, Gréen, Henrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7891621/
https://www.ncbi.nlm.nih.gov/pubmed/32749741
http://dx.doi.org/10.1002/dta.2906