Cargando…
Comparative analysis of heparin affecting the biochemical properties of chicken and murine prion proteins
The conversion of cellular prion protein (PrP(C)) to disease-provoking conformer (PrP(Sc)) is crucial in the pathogenesis of prion diseases. Heparin has been shown to enhance mammalian prion protein misfolding. As spontaneous prion disease has not been reported in non-mammalian species, such as chic...
| Autores principales: | , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2021
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7891698/ https://www.ncbi.nlm.nih.gov/pubmed/33600459 http://dx.doi.org/10.1371/journal.pone.0247248 |