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Downregulation of lncRNA MIR181A2HG by high glucose impairs vascular endothelial cell proliferation and migration through the dysregulation of the miRNAs/AKT2 axis

Endothelial dysfunction and diabetic vascular disease induced by chronic hyperglycemia involve complex interactions among high glucose, long non-coding RNAs (lncRNAs), microRNAs (miRNAs or miRs) and the Ser/Thr kinase AKT. However, the molecular mechanisms under-lying the regulatory crosstalk betwee...

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Detalles Bibliográficos
Autores principales: Wang, Shaohua, Zheng, Bin, Zhao, Hongye, Li, Yongjun, Zhang, Xinhua, Wen, Jinkun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7891834/
https://www.ncbi.nlm.nih.gov/pubmed/33537821
http://dx.doi.org/10.3892/ijmm.2021.4868