Hypoxia-induced CREB cooperates MMSET to modify chromatin and promote DKK1 expression in multiple myeloma

Myeloma cells produce excessive levels of dickkopf-1 (DKK1), which mediates the inhibition of Wnt signaling in osteoblasts, leading to multiple myeloma (MM) bone disease. Nevertheless, the precise mechanisms underlying DKK1 overexpression in myeloma remain incompletely understood. Herein, we provide...

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Detalles Bibliográficos
Autores principales: Xu, Yinyin, Guo, Jing, Liu, Jing, Xie, Ying, Li, Xin, Jiang, Hongmei, Wang, Jingjing, Peng, Ziyi, Wang, Jingya, Wang, Sheng, Wan, Chao, Chen, Lanting, Zhong, Yuping, Liu, Beizhong, Liu, Zhiqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7892339/
https://www.ncbi.nlm.nih.gov/pubmed/33420361
http://dx.doi.org/10.1038/s41388-020-01590-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7892339/
https://www.ncbi.nlm.nih.gov/pubmed/33420361
http://dx.doi.org/10.1038/s41388-020-01590-8

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