β-Trcp and CK1δ-mediated degradation of LZTS2 activates PI3K/AKT signaling to drive tumorigenesis and metastasis in hepatocellular carcinoma

Distant metastasis is the leading cause of treatment failure in patients with hepatocellular carcinoma (HCC). However, the underlying mechanisms have not been fully elucidated. Here, we report that Leucine zipper tumor suppressor 2 (LZTS2) is downregulated and correlated with poor prognosis in HCC....

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Detalles Bibliográficos
Autores principales: Lu, Yanwei, Li, Xudong, Liu, Hongli, Xue, Jun, Zeng, Zhen, Dong, Xiaorong, Zhang, Tao, Wu, Gang, Yang, Kunyu, Xu, Shuangbing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7892348/
https://www.ncbi.nlm.nih.gov/pubmed/33420362
http://dx.doi.org/10.1038/s41388-020-01596-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7892348/
https://www.ncbi.nlm.nih.gov/pubmed/33420362
http://dx.doi.org/10.1038/s41388-020-01596-2

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