Eltrombopag directly inhibits BAX and prevents cell death

The BCL-2 family protein BAX has essential activity in mitochondrial regulation of cell death. While BAX activity ensures tissue homeostasis, when dysregulated it contributes to aberrant cell death in several diseases. During cellular stress BAX is transformed from an inactive cytosolic conformation...

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Detalles Bibliográficos
Autores principales: Spitz, Adam Z., Zacharioudakis, Emmanouil, Reyna, Denis E., Garner, Thomas P., Gavathiotis, Evripidis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7892824/
https://www.ncbi.nlm.nih.gov/pubmed/33602934
http://dx.doi.org/10.1038/s41467-021-21224-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7892824/
https://www.ncbi.nlm.nih.gov/pubmed/33602934
http://dx.doi.org/10.1038/s41467-021-21224-1

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