Cargando…

Sophisticated viral quasispecies with a genotype-related pattern of mutations in the hepatitis B X gene of HBeAg-ve chronically infected patients

Patients with HBeAg-negative chronic infection (CI) have not been extensively studied because of low viremia. The HBx protein, encoded by HBX, has a key role in viral replication. Here, we analyzed the viral quasispecies at the 5′ end of HBX in CI patients and compared it with that of patients in ot...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cortese, Maria Francesca, González, Carolina, Gregori, Josep, Casillas, Rosario, Carioti, Luca, Guerrero-Murillo, Mercedes, Riveiro-Barciela, Mar, Godoy, Cristina, Sopena, Sara, Yll, Marçal, Quer, Josep, Rando, Ariadna, Lopez-Martinez, Rosa, Pacín Ruiz, Beatriz, García-García, Selene, Esteban-Mur, Rafael, Tabernero, David, Buti, Maria, Rodríguez-Frías, Francisco
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7892877/ https://www.ncbi.nlm.nih.gov/pubmed/33603102 http://dx.doi.org/10.1038/s41598-021-83762-4

Ejemplares similares

Characterization of hepatitis B virus X gene quasispecies complexity in mono-infection and hepatitis delta virus superinfection
por: Godoy, Cristina, et al.
Publicado: (2019)

Cross-sectional evaluation of circulating hepatitis B virus RNA and DNA: Different quasispecies?
por: Garcia-Garcia, Selene, et al.
Publicado: (2021)

HBsAg protein composition and clinical outcomes in chronic hepatitis D and variations across HBeAg-negative chronic HBsAg carriers
por: Roade, Luisa, et al.
Publicado: (2023)

Detection of hyper-conserved regions in hepatitis B virus X gene potentially useful for gene therapy
por: González, Carolina, et al.
Publicado: (2018)

ACE Score Identifies HBeAg-negative Inactive Carriers at a Single-point Evaluation, Regardless of HBV Genotype
por: Roade, Luisa, et al.
Publicado: (2022)

Hepatitis B Virus Variants with Multiple Insertions and/or Deletions in the X Open Reading Frame 3′ End: Common Members of Viral Quasispecies in Chronic Hepatitis B Patients
por: García-García, Selene, et al.
Publicado: (2022)

Conservation and variability of hepatitis B core at different chronic hepatitis stages
por: Yll, Marçal, et al.
Publicado: (2020)

Evidence of an Exponential Decay Pattern of the Hepatitis Delta Virus Evolution Rate and Fluctuations in Quasispecies Complexity in Long-Term Studies of Chronic Delta Infection
por: Homs, Maria, et al.
Publicado: (2016)

Inspecting the Ribozyme Region of Hepatitis Delta Virus Genotype 1: Conservation and Variability
por: Pacin-Ruiz, Beatriz, et al.
Publicado: (2022)

Standardized Hepatitis B Virus RNA Quantification in Untreated and Treated Chronic Patients: a Promising Marker of Infection Follow-Up
por: Cortese, Maria Francesca, et al.
Publicado: (2022)

Whole genome deep sequencing analysis of viral quasispecies diversity and evolution in HBeAg seroconverters
por: Lin, Su-Ru, et al.
Publicado: (2021)

Quasispecies Fitness Partition to Characterize the Molecular Status of a Viral Population. Negative Effect of Early Ribavirin Discontinuation in a Chronically Infected HEV Patient
por: Gregori, Josep, et al.
Publicado: (2022)

Quantifying In-Host Quasispecies Evolution
por: Gregori, Josep, et al.
Publicado: (2023)

Clinical Application of Estimating Hepatitis B Virus Quasispecies Complexity by Massive Sequencing: Correlation between Natural Evolution and On-Treatment Evolution
por: Homs, Maria, et al.
Publicado: (2014)

Correlations of HBV Genotypes, Mutations Affecting HBeAg Expression and HBeAg/ anti-HBe Status in HBV Carriers
por: Lim, Chee Kent, et al.
Publicado: (2006)

Complex Genotype Mixtures Analyzed by Deep Sequencing in Two Different Regions of Hepatitis B Virus
por: Caballero, Andrea, et al.
Publicado: (2015)

Analysis of hepatitis B virus preS1 variability and prevalence of the rs2296651 polymorphism in a Spanish population
por: Casillas, Rosario, et al.
Publicado: (2018)

Is the function of the HBeAg really unknown?
por: Milich, David R.
Publicado: (2019)

Differential Plasma MicroRNA Profiles in HBeAg Positive and HBeAg Negative Children with Chronic Hepatitis B
por: Winther, Thilde Nordmann, et al.
Publicado: (2013)

Prediction of early HBeAg seroconversion by decreased titers of HBeAg in the serum combined with increased grades of lobular inflammation in the liver
por: Bae, Sung Kwan, et al.
Publicado: (2012)

Manifestations of Perihepatic Lymph Nodes in Acute Flare of Chronic Hepatitis B: Association with HBeAg Status and with HBeAg Seroconversion
por: Ko, Yen-Ling, et al.
Publicado: (2015)

HBV pregenome RNA as a predictor of spontanous HBeAg seroconversion in HBeAg-positive chronic hepatitis B patients
por: Song, Guangjun, et al.
Publicado: (2023)

The cost-effectiveness of long-term antiviral therapy in the management of HBeAg-positive and HBeAg-negative chronic hepatitis B in Singapore
por: Lacey, L F, et al.
Publicado: (2007)

Impact of Drug-Resistance Polymerase Mutations on the Replication of HBeAg-Positive and HBeAg-Negative Hepatitis B Virus Strains in Vitro
por: Tacke, Frank, et al.
Publicado: (2012)

HBsAg as an important predictor of HBeAg seroconversion following antiviral treatment for HBeAg-positive chronic hepatitis B patients
por: Yang, Jiezuan, et al.
Publicado: (2014)

Different interventional criteria for chronic hepatitis B pregnant women with HBeAg(+) or HBeAg(-): Epidemiological data from Shaanxi, China
por: Chen, Tianyan, et al.
Publicado: (2018)

Cirrhosis, Liver Transplantation and HIV Infection Are Risk Factors Associated with Hepatitis E Virus Infection
por: Riveiro-Barciela, Mar, et al.
Publicado: (2014)

HBsAg and HBeAg in the prediction of a clinical response to peginterferon α-2b therapy in Chinese HBeAg-positive patients
por: Yang, Song, et al.
Publicado: (2016)

Study of Quasispecies Complexity and Liver Damage Progression after Liver Transplantation in Hepatitis C Virus Infected Patients
por: Llorens-Revull, Meritxell, et al.
Publicado: (2021)

Analysis of clinical and virologic features in Hepatitis B e Antigen (HbeAg)-negative and HbeAg-positive Egyptian chronic hepatitis B patients
por: Fouad, Rabab, et al.
Publicado: (2020)

Viral Biomarkers in Chronic HBeAg Negative HBV Infection
por: Hadziyannis, Emilia, et al.
Publicado: (2018)

Implementation of anti-HDV reflex testing among HBsAg-positive individuals increases testing for hepatitis D
por: Palom, Adriana, et al.
Publicado: (2022)

Comparison of Serum Hepatitis B Virus DNA and HBsAg Levels Between HBeAg-Negative and HBeAg-Positive Chronic Hepatitis B Patients
por: Keshvari, Maryam, et al.
Publicado: (2015)

Whole exome HBV DNA integration is independent of the intrahepatic HBV reservoir in HBeAg-negative chronic hepatitis B
por: Svicher, Valentina, et al.
Publicado: (2021)

HBeAg-Negative/Anti-HBe-Positive Chronic Hepatitis B: A 40-Year-Old History
por: Bonino, Ferruccio, et al.
Publicado: (2022)

Study on Post-Treatment Relapse in HBeAg Positive CHB Patients
por: Lu, Junfeng, et al.
Publicado: (2015)

The clinical implications of hepatitis B virus genotypes and HBeAg in pediatrics
por: Kramvis, Anna
Publicado: (2016)

Characteristics of an Outpatient Cohort with HBeAg-Negative Chronic Hepatitis B
por: Dimzova, Marija, et al.
Publicado: (2019)

The Complex Role of HBeAg and Its Precursors in the Pathway to Hepatocellular Carcinoma
por: Padarath, Kiyasha, et al.
Publicado: (2023)

A cautionary note to hepatitis B e antigen (HBeAg)‐negative test results in pregnant women in an area prevalent of HBeAg‐negative chronic hepatitis B
por: Chalid, Maisuri T., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_iqrksmrt2drjldbt15161j1neo