Signaling Heterogeneity is Defined by Pathway Architecture and Intercellular Variability in Protein Expression

Insulin's activation of PI3K/Akt signaling, stimulates glucose uptake by enhancing delivery of GLUT4 to the cell surface. Here we examined the origins of intercellular heterogeneity in insulin signaling. Akt activation alone accounted for ~25% of the variance in GLUT4, indicating that additiona...

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Detalles Bibliográficos
Autores principales: Norris, Dougall, Yang, Pengyi, Shin, Sung-Young, Kearney, Alison L., Kim, Hani Jieun, Geddes, Thomas, Senior, Alistair M., Fazakerley, Daniel J., Nguyen, Lan K., James, David E., Burchfield, James G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7892930/
https://www.ncbi.nlm.nih.gov/pubmed/33659881
http://dx.doi.org/10.1016/j.isci.2021.102118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7892930/
https://www.ncbi.nlm.nih.gov/pubmed/33659881
http://dx.doi.org/10.1016/j.isci.2021.102118

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