Cargando…
Signaling Heterogeneity is Defined by Pathway Architecture and Intercellular Variability in Protein Expression
Insulin's activation of PI3K/Akt signaling, stimulates glucose uptake by enhancing delivery of GLUT4 to the cell surface. Here we examined the origins of intercellular heterogeneity in insulin signaling. Akt activation alone accounted for ~25% of the variance in GLUT4, indicating that additiona...
| Autores principales: | , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2021
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7892930/ https://www.ncbi.nlm.nih.gov/pubmed/33659881 http://dx.doi.org/10.1016/j.isci.2021.102118 |