Broad cross protection by recombinant live attenuated influenza H3N2 seasonal virus expressing conserved M2 extracellular domain in a chimeric hemagglutinin

Hemagglutinin (HA)-based current vaccines provide suboptimum cross protection. Influenza A virus contains an ion channel protein M2 conserved extracellular domain (M2e), a target for developing universal vaccines. Here we generated reassortant influenza virus rgH3N2 4xM2e virus (HA and NA from A/Swi...

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Detalles Bibliográficos
Autores principales: Park, Bo Ryoung, Kim, Ki-Hye, Kotomina, Tatiana, Kim, Min-Chul, Kwon, Young-Man, Jeeva, Subbiah, Jung, Yu-Jin, Bhatnagar, Noopur, Isakova-Sivak, Irina, Mezhenskaya, Daria, Rudenko, Larisa, Wang, Bao-Zhong, Kang, Sang-Moo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7893060/
https://www.ncbi.nlm.nih.gov/pubmed/33603072
http://dx.doi.org/10.1038/s41598-021-83704-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7893060/
https://www.ncbi.nlm.nih.gov/pubmed/33603072
http://dx.doi.org/10.1038/s41598-021-83704-0

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