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RSPO4-CRISPR alleviates liver injury and restores gut microbiota in a rat model of liver fibrosis
Wnt signaling dysfunction and gut dysbiosis may lead to liver fibrosis, yet the underlying mechanisms are not well elucidated. This study demonstrated the role of RSPO4, a Wnt signaling agonist, in liver fibrogenesis and its impact on the gut microbiome. RSPO4 gene in CCl(4)-induced fibrotic-liver r...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7893072/ https://www.ncbi.nlm.nih.gov/pubmed/33603089 http://dx.doi.org/10.1038/s42003-021-01747-5 |