Antagonizing the spindle assembly checkpoint silencing enhances paclitaxel and Navitoclax-mediated apoptosis with distinct mechanistic

Antimitotic drugs arrest cells in mitosis through chronic activation of the spindle assembly checkpoint (SAC), leading to cell death. However, drug-treated cancer cells can escape death by undergoing mitotic slippage, due to premature mitotic exit. Therefore, overcoming slippage issue is a promising...

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Detalles Bibliográficos
Autores principales: Henriques, Ana C., Silva, Patrícia M. A., Sarmento, Bruno, Bousbaa, Hassan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7893169/
https://www.ncbi.nlm.nih.gov/pubmed/33603057
http://dx.doi.org/10.1038/s41598-021-83743-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7893169/
https://www.ncbi.nlm.nih.gov/pubmed/33603057
http://dx.doi.org/10.1038/s41598-021-83743-7

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