IDH2 gene deficiency accelerates unilateral ureteral obstruction-induced kidney inflammation through oxidative stress and activation of macrophages

Mitochondrial NADP(+)-dependent isocitrate dehydrogenase 2 (IDH2) produces NADPH, which is known to inhibit mitochondrial oxidative stress. Ureteral obstruction induces kidney inflammation and fibrosis via oxidative stress. Here, we investigated the role and underlying mechanism of IDH2 in unilatera...

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Detalles Bibliográficos
Autores principales: Kim, Jee In, Noh, Mi Ra, Yoon, Ga-Eun, Jang, Hee-Seong, Kong, Min Jung, Park, Kwon Moo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Physiological Society and The Korean Society of Pharmacology 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7893493/
https://www.ncbi.nlm.nih.gov/pubmed/33602884
http://dx.doi.org/10.4196/kjpp.2021.25.2.139

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7893493/
https://www.ncbi.nlm.nih.gov/pubmed/33602884
http://dx.doi.org/10.4196/kjpp.2021.25.2.139

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