27-Hydroxycholesterol induces macrophage gene expression via LXR-dependent and -independent mechanisms

27-Hydroxycholesterol (27OHChol) exhibits agonistic activity for liver X receptors (LXRs). To determine roles of the LXR agonistic activity in macrophage gene expression, we investigated the effects of LXR inhibition on the 27OHChol-induced genes. Treatment of human THP-1 cells with GSK 2033, a pote...

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Detalles Bibliográficos
Autores principales: Kim, Bo-Young, Son, Yonghae, Cho, Hyok-rae, Lee, Dongjun, Eo, Seong-Kug, Kim, Koanhoi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Physiological Society and The Korean Society of Pharmacology 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7893494/
https://www.ncbi.nlm.nih.gov/pubmed/33602881
http://dx.doi.org/10.4196/kjpp.2021.25.2.111

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7893494/
https://www.ncbi.nlm.nih.gov/pubmed/33602881
http://dx.doi.org/10.4196/kjpp.2021.25.2.111

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