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27-Hydroxycholesterol induces macrophage gene expression via LXR-dependent and -independent mechanisms

27-Hydroxycholesterol (27OHChol) exhibits agonistic activity for liver X receptors (LXRs). To determine roles of the LXR agonistic activity in macrophage gene expression, we investigated the effects of LXR inhibition on the 27OHChol-induced genes. Treatment of human THP-1 cells with GSK 2033, a pote...

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Detalles Bibliográficos
Autores principales:	Kim, Bo-Young, Son, Yonghae, Cho, Hyok-rae, Lee, Dongjun, Eo, Seong-Kug, Kim, Koanhoi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Korean Physiological Society and The Korean Society of Pharmacology 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7893494/ https://www.ncbi.nlm.nih.gov/pubmed/33602881 http://dx.doi.org/10.4196/kjpp.2021.25.2.111

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