Predicting Mixture Effects over Time with Toxicokinetic–Toxicodynamic Models (GUTS): Assumptions, Experimental Testing, and Predictive Power

[Image: see text] Current methods to assess the impact of chemical mixtures on organisms ignore the temporal dimension. The General Unified Threshold model for Survival (GUTS) provides a framework for deriving toxicokinetic–toxicodynamic (TKTD) models, which account for effects of toxicant exposure...

Descripción completa

Detalles Bibliográficos
Autores principales: Bart, Sylvain, Jager, Tjalling, Robinson, Alex, Lahive, Elma, Spurgeon, David J., Ashauer, Roman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7893709/
https://www.ncbi.nlm.nih.gov/pubmed/33499591
http://dx.doi.org/10.1021/acs.est.0c05282

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7893709/
https://www.ncbi.nlm.nih.gov/pubmed/33499591
http://dx.doi.org/10.1021/acs.est.0c05282

Ejemplares similares