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Predicting Mixture Effects over Time with Toxicokinetic–Toxicodynamic Models (GUTS): Assumptions, Experimental Testing, and Predictive Power

[Image: see text] Current methods to assess the impact of chemical mixtures on organisms ignore the temporal dimension. The General Unified Threshold model for Survival (GUTS) provides a framework for deriving toxicokinetic–toxicodynamic (TKTD) models, which account for effects of toxicant exposure...

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Detalles Bibliográficos
Autores principales:	Bart, Sylvain, Jager, Tjalling, Robinson, Alex, Lahive, Elma, Spurgeon, David J., Ashauer, Roman
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2021
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7893709/ https://www.ncbi.nlm.nih.gov/pubmed/33499591 http://dx.doi.org/10.1021/acs.est.0c05282

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