Critical roles of sphingosine kinase 1 in the regulation of neuroinflammation and neuronal injury after spinal cord injury

BACKGROUND: The pathological process of traumatic spinal cord injury (SCI) involves excessive activation of microglia leading to the overproduction of proinflammatory cytokines and causing neuronal injury. Sphingosine kinase 1 (Sphk1), a key enzyme responsible for phosphorylating sphingosine into sp...

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Detalles Bibliográficos
Autores principales: Wang, Chenjian, Xu, Tianzhen, Lachance, Brittany Bolduc, Zhong, Xiqiang, Shen, Guangjie, Xu, Tao, Tang, Chengxuan, Jia, Xiaofeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7893778/
https://www.ncbi.nlm.nih.gov/pubmed/33602274
http://dx.doi.org/10.1186/s12974-021-02092-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7893778/
https://www.ncbi.nlm.nih.gov/pubmed/33602274
http://dx.doi.org/10.1186/s12974-021-02092-4

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