Structural basis of nucleosomal histone H4 lysine 20 methylation by SET8 methyltransferase

SET8 is solely responsible for histone H4 lysine-20 (H4K20) monomethylation, which preferentially occurs in nucleosomal H4. However, the underlying mechanism by which SET8 specifically promotes the H4K20 monomethylation in the nucleosome has not been elucidated. Here, we report the cryo-EM structure...

Descripción completa

Detalles Bibliográficos
Autores principales: Ho, Cheng-Han, Takizawa, Yoshimasa, Kobayashi, Wataru, Arimura, Yasuhiro, Kimura, Hiroshi, Kurumizaka, Hitoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7893823/
https://www.ncbi.nlm.nih.gov/pubmed/33574035
http://dx.doi.org/10.26508/lsa.202000919

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7893823/
https://www.ncbi.nlm.nih.gov/pubmed/33574035
http://dx.doi.org/10.26508/lsa.202000919

Ejemplares similares