Development of genome-wide polygenic risk scores for lipid traits and clinical applications for dyslipidemia, subclinical atherosclerosis, and diabetes cardiovascular complications among East Asians

BACKGROUND: The clinical utility of personal genomic information in identifying individuals at increased risks for dyslipidemia and cardiovascular diseases remains unclear. METHODS: We used data from Biobank Japan (n = 70,657–128,305) and developed novel East Asian-specific genome-wide polygenic ris...

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Detalles Bibliográficos
Autores principales: Tam, Claudia H. T., Lim, Cadmon K. P., Luk, Andrea O. Y., Ng, Alex C. W., Lee, Heung-man, Jiang, Guozhi, Lau, Eric S. H., Fan, Baoqi, Wan, Raymond, Kong, Alice P. S., Tam, Wing-hung, Ozaki, Risa, Chow, Elaine Y. K., Lee, Ka-fai, Siu, Shing-chung, Hui, Grace, Tsang, Chiu-chi, Lau, Kam-piu, Leung, Jenny Y. Y., Tsang, Man-wo, Kam, Grace, Lau, Ip-tim, Li, June K. Y., Yeung, Vincent T. F., Lau, Emmy, Lo, Stanley, Fung, Samuel, Cheng, Yuk-lun, Chow, Chun-chung, Hu, Miao, Yu, Weichuan, Tsui, Stephen K. W., Huang, Yu, Lan, Huiyao, Szeto, Cheuk-chun, Tang, Nelson L. S., Ng, Maggie C. Y., So, Wing-yee, Tomlinson, Brian, Chan, Juliana C. N., Ma, Ronald C. W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7893928/
https://www.ncbi.nlm.nih.gov/pubmed/33608049
http://dx.doi.org/10.1186/s13073-021-00831-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7893928/
https://www.ncbi.nlm.nih.gov/pubmed/33608049
http://dx.doi.org/10.1186/s13073-021-00831-z

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