SRPK1/2 and PP1α exert opposite functions by modulating SRSF1-guided MKNK2 alternative splicing in colon adenocarcinoma

BACKGROUND: The Mnk2 kinase, encoded by MKNK2 gene, plays critical roles in MAPK signaling and was involved in oncogenesis. Human MKNK2 pre-mRNA can be alternatively spliced into two splicing isoforms, the MKNK2a and MKNK2b, thus yielding Mnk2a and Mnk2b proteins with different domains. The involvem...

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Detalles Bibliográficos
Autores principales: Liu, Hongda, Gong, Zheng, Li, Kangshuai, Zhang, Qun, Xu, Zekuan, Xu, Yunfei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7893936/
https://www.ncbi.nlm.nih.gov/pubmed/33602301
http://dx.doi.org/10.1186/s13046-021-01877-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7893936/
https://www.ncbi.nlm.nih.gov/pubmed/33602301
http://dx.doi.org/10.1186/s13046-021-01877-y

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