Stabilizing AqdC, a Pseudomonas Quinolone Signal‐Cleaving Dioxygenase from Mycobacteria, by FRESCO‐Based Protein Engineering

The mycobacterial PQS dioxygenase AqdC, a cofactor‐less protein with an α/β‐hydrolase fold, inactivates the virulence‐associated quorum‐sensing signal molecule 2‐heptyl‐3‐hydroxy‐4(1H)‐quinolone (PQS) produced by the opportunistic pathogen Pseudomonas aeruginosa and is therefore a potential anti‐vir...

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Detalles Bibliográficos
Autores principales: Wullich, Sandra C., Wijma, Hein J., Janssen, Dick B., Fetzner, Susanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7894191/
https://www.ncbi.nlm.nih.gov/pubmed/33058333
http://dx.doi.org/10.1002/cbic.202000641

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7894191/
https://www.ncbi.nlm.nih.gov/pubmed/33058333
http://dx.doi.org/10.1002/cbic.202000641

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