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System‐level analyses of keystone genes required for mammalian tooth development

When a null mutation of a gene causes a complete developmental arrest, the gene is typically considered essential for life. Yet, in most cases, null mutations have more subtle effects on the phenotype. Here we used the phenotypic severity of mutations as a tool to examine system‐level dynamics of ge...

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Detalles Bibliográficos
Autores principales: Hallikas, Outi, Das Roy, Rishi, Christensen, Mona M., Renvoisé, Elodie, Sulic, Ana‐Marija, Jernvall, Jukka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7894285/
https://www.ncbi.nlm.nih.gov/pubmed/33128445
http://dx.doi.org/10.1002/jez.b.23009