Model‐Based Meta‐Analysis Compares DAS28 Rheumatoid Arthritis Treatment Effects and Suggests an Expedited Trial Design for Early Clinical Development

A nonlinear mixed effects modeling approach was used to conduct a model‐based meta‐analysis (MBMA) of longitudinal, summary‐level, baseline‐corrected 28‐joint Disease Activity Score (ΔDAS28) clinical trial data from seven approved rheumatoid arthritis (RA) drugs (abatacept, adalimumab, certolizumab,...

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Detalles Bibliográficos
Autores principales: Leil, Tarek A., Lu, Yasong, Bouillon‐Pichault, Marion, Wong, Robert, Nowak, Miroslawa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7894503/
https://www.ncbi.nlm.nih.gov/pubmed/32860421
http://dx.doi.org/10.1002/cpt.2023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7894503/
https://www.ncbi.nlm.nih.gov/pubmed/32860421
http://dx.doi.org/10.1002/cpt.2023

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