A High‐Yielding Synthesis of EIDD‐2801 from Uridine

A simple reordering of the reaction sequence allowed the improved synthesis of EIDD‐2801, an antiviral drug with promising activity against the SARS‐CoV‐2 virus, starting from uridine. Compared to the original route, the yield was enhanced from 17 % to 61 %, and fewer isolation/purification steps we...

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Detalles Bibliográficos
Autores principales: Steiner, Alexander, Znidar, Desiree, Ötvös, Sándor B., Snead, David R., Dallinger, Doris, Kappe, C. Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7894511/
https://www.ncbi.nlm.nih.gov/pubmed/33664631
http://dx.doi.org/10.1002/ejoc.202001340

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7894511/
https://www.ncbi.nlm.nih.gov/pubmed/33664631
http://dx.doi.org/10.1002/ejoc.202001340

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