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C‐Terminal Tag Location Hampers in Vitro Profiling of OGT Peptide Substrates by mRNA Display

O‐GlcNAc transferase (OGT) is the only enzyme that catalyzes the post‐translational modification of proteins at Ser/Thr with a single β‐N‐acetylglucosamine (O‐GlcNAcylation). Its activity has been associated with chronic diseases such as cancer, diabetes and neurodegenerative disease. Although numer...

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Detalles Bibliográficos
Autores principales: Shi, Jie, Sharif, Suhela, Balsollier, Cyril, Ruijtenbeek, Rob, Pieters, Roland J., Jongkees, Seino A. K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7894566/
https://www.ncbi.nlm.nih.gov/pubmed/33022805
http://dx.doi.org/10.1002/cbic.202000624