Recent Achievements and Challenges in Prolonging the Serum Half-Lives of Therapeutic IgG Antibodies Through Fc Engineering

Association of FcRn molecules to the Fc region of IgG in acidified endosomes and subsequent dissociation of the interaction in neutral pH serum enables IgG molecules to be recycled for prolonged serum persistence after internalization by endothelial cells, rather than being degraded in the serum and...

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Detalles Bibliográficos
Autores principales: Ko, Sanghwan, Jo, Migyeong, Jung, Sang Taek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7894971/
https://www.ncbi.nlm.nih.gov/pubmed/33608823
http://dx.doi.org/10.1007/s40259-021-00471-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7894971/
https://www.ncbi.nlm.nih.gov/pubmed/33608823
http://dx.doi.org/10.1007/s40259-021-00471-0

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