The C3/465 glycan hole cluster in BG505 HIV-1 envelope is the major neutralizing target involved in preventing mucosal SHIV infection

Stabilized HIV-1 envelope (Env) trimers elicit tier 2 autologous neutralizing antibody (nAb) responses in immunized animals. We previously demonstrated that BG505 SOSIP.664.T332N gp140 (BG505 SOSIP) immunization of rhesus macaques (RM) provided robust protection against autologous intra-vaginal simi...

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Detalles Bibliográficos
Autores principales: Charles, Tysheena P., Burton, Samantha L., Arunachalam, Prabhu S., Cottrell, Christopher A., Sewall, Leigh M., Bollimpelli, Venkata S., Gangadhara, Sailaja, Dey, Antu K., Ward, Andrew B., Shaw, George M., Hunter, Eric, Amara, Rama R., Pulendran, Bali, van Gils, Marit J., Derdeyn, Cynthia A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7895394/
https://www.ncbi.nlm.nih.gov/pubmed/33556148
http://dx.doi.org/10.1371/journal.ppat.1009257

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7895394/
https://www.ncbi.nlm.nih.gov/pubmed/33556148
http://dx.doi.org/10.1371/journal.ppat.1009257

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