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The C3/465 glycan hole cluster in BG505 HIV-1 envelope is the major neutralizing target involved in preventing mucosal SHIV infection
Stabilized HIV-1 envelope (Env) trimers elicit tier 2 autologous neutralizing antibody (nAb) responses in immunized animals. We previously demonstrated that BG505 SOSIP.664.T332N gp140 (BG505 SOSIP) immunization of rhesus macaques (RM) provided robust protection against autologous intra-vaginal simi...
Autores principales: | Charles, Tysheena P., Burton, Samantha L., Arunachalam, Prabhu S., Cottrell, Christopher A., Sewall, Leigh M., Bollimpelli, Venkata S., Gangadhara, Sailaja, Dey, Antu K., Ward, Andrew B., Shaw, George M., Hunter, Eric, Amara, Rama R., Pulendran, Bali, van Gils, Marit J., Derdeyn, Cynthia A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7895394/ https://www.ncbi.nlm.nih.gov/pubmed/33556148 http://dx.doi.org/10.1371/journal.ppat.1009257 |
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